Ontology highlight
ABSTRACT:
SUBMITTER: Casas JP
PROVIDER: S-EPMC3377948 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Casas Juan P JP Ninio Ewa E Panayiotou Andrie A Palmen Jutta J Cooper Jackie A JA Ricketts Sally L SL Sofat Reecha R Nicolaides Andrew N AN Corsetti James P JP Fowkes F Gerry R FG Tzoulaki Ioanna I Kumari Meena M Brunner Eric J EJ Kivimaki Mika M Marmot Michael G MG Hoffmann Michael M MM Winkler Karl K März Winfred W Ye Shu S Stirnadel Heide A HA Boekholdt S Matthijs SM Khaw Kay-Tee KT Humphries Steve E SE Sandhu Manjinder S MS Hingorani Aroon D AD Talmud Philippa J PJ
Circulation 20100517 21
<h4>Background</h4>Higher lipoprotein-associated phospholipase A(2)(Lp-PLA2) activity is associated with increased risk of coronary heart disease (CHD), making Lp-PLA2 a potential therapeutic target. PLA2G7 variants associated with Lp-PLA2 activity could evaluate whether this relationship is causal.<h4>Methods and results</h4>A meta-analysis including a total of 12 studies (5 prospective, 4 case-control, 1 case-only, and 2 cross-sectional studies; n=26 118) was undertaken to examine the associat ...[more]