Ontology highlight
ABSTRACT:
SUBMITTER: Xie LH
PROVIDER: S-EPMC3378074 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Xie Lai-Hua LH Shanmugam Mayilvahanan M Park Ji Yeon JY Zhao Zhenghang Z Wen Hairuo H Tian Bin B Periasamy Muthu M Babu Gopal J GJ
American journal of physiology. Cell physiology 20120411 12
Sarcolipin (SLN) is a key regulator of sarco(endo)plasmic reticulum (SR) Ca(2+)-ATPase (SERCA), and its expression is altered in diseased atrial myocardium. To determine the precise role of SLN in atrial Ca(2+) homeostasis, we developed a SLN knockout (sln-/-) mouse model and demonstrated that ablation of SLN enhances atrial SERCA pump activity. The present study is designed to determine the long-term effects of enhanced SERCA activity on atrial remodeling in the sln-/- mice. Calcium transient m ...[more]