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Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European ppulations.


ABSTRACT: BACKGROUND:Individuals with higher blood 25-hydroxyvitamin D [25(OH)D] levels have a lower risk of developing colorectal cancer (CRC), but the influence of 25(OH)D on mortality after CRC diagnosis is unknown. METHODS:The association between prediagnostic 25(OH)D levels and CRC-specific (N = 444) and overall mortality (N = 541) was prospectively examined among 1,202 participants diagnosed with CRC between 1992 and 2003 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate HRs and corresponding 95% CIs according to 25(OH)D quintiles and genetic variation within the VDR and CASR genes. Potential dietary, lifestyle, and metabolic effect modifiers were also investigated. RESULTS:There were 541 deaths, 444 (82%) due to CRC. Mean follow-up was 73 months. In multivariable analysis, higher 25(OH)D levels were associated with a statistically significant reduction in CRC-specific (P(trend) = 0.04) and overall mortality (P(trend) = 0.01). Participants with 25(OH)D levels in the highest quintile had an adjusted HR of 0.69 (95% CI: 0.50-0.93) for CRC-specific mortality and 0.67 (95% CI: 0.50-0.88) for overall mortality, compared with the lowest quintile. Except for a possible interaction by prediagnostic dietary calcium intake (P(interaction) = 0.01), no other potential modifying factors related to CRC survival were noted. The VDR (FokI and BsmI) and CASR (rs1801725) genotypes were not associated with survival. CONCLUSIONS:High prediagnostic 25(OH)D levels are associated with improved survival of patients with CRC. IMPACT:Our findings may stimulate further research directed at investigating the effects of blood vitamin D levels before, at, and after CRC diagnosis on outcomes in CRC patients.

SUBMITTER: Fedirko V 

PROVIDER: S-EPMC3378514 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European ppulations.

Fedirko Veronika V   Riboli Elio E   Tjønneland Anne A   Ferrari Pietro P   Olsen Anja A   Bueno-de-Mesquita H Bas HB   van Duijnhoven Fränzel J B FJ   Norat Teresa T   Jansen Eugène H J M EH   Dahm Christina C CC   Overvad Kim K   Boutron-Ruault Marie-Christine MC   Clavel-Chapelon Françoise F   Racine Antoine A   Lukanova Annekatrin A   Teucher Birgit B   Boeing Heiner H   Aleksandrova Krasimira K   Trichopoulou Antonia A   Benetou Vassiliki V   Trichopoulos Dimitrios D   Grioni Sara S   Vineis Paolo P   Panico Salvatore S   Palli Domenico D   Tumino Rosario R   Siersema Peter D PD   Peeters Petra H PH   Skeie Guri G   Brustad Magritt M   Chirlaque Maria-Dolores MD   Barricarte Aurelio A   Ramón Quirós Jose J   Sánchez Maria José MJ   Dorronsoro Miren M   Bonet Catalina C   Palmqvist Richard R   Hallmans Göran G   Key Timothy J TJ   Crowe Francesca F   Khaw Kay-Tee KT   Wareham Nick N   Romieu Isabelle I   McKay James J   Wark Petra A PA   Romaguera Dora D   Jenab Mazda M  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20120125 4


<h4>Background</h4>Individuals with higher blood 25-hydroxyvitamin D [25(OH)D] levels have a lower risk of developing colorectal cancer (CRC), but the influence of 25(OH)D on mortality after CRC diagnosis is unknown.<h4>Methods</h4>The association between prediagnostic 25(OH)D levels and CRC-specific (N = 444) and overall mortality (N = 541) was prospectively examined among 1,202 participants diagnosed with CRC between 1992 and 2003 in the European Prospective Investigation into Cancer and Nutri  ...[more]

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