TRPA1 is a polyunsaturated fatty acid sensor in mammals.
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ABSTRACT:
SUBMITTER: Motter AL
PROVIDER: S-EPMC3378573 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
TRPA1 is a polyunsaturated fatty acid sensor in mammals.
Motter Arianne L AL Ahern Gerard P GP
PloS one 20120619 6
Fatty acids can act as important signaling molecules regulating diverse physiological processes. Our understanding, however, of fatty acid signaling mechanisms and receptor targets remains incomplete. Here we show that Transient Receptor Potential Ankyrin 1 (TRPA1), a cation channel expressed in sensory neurons and gut tissues, functions as a sensor of polyunsaturated fatty acids (PUFAs) in vitro and in vivo. PUFAs, containing at least 18 carbon atoms and three unsaturated bonds, activate TRPA1 ...[more]
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