Ontology highlight
ABSTRACT:
SUBMITTER: Kanga S
PROVIDER: S-EPMC3378586 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20120619 6
The ubiquitin system is known to be involved in maintaining the integrity of mitochondria, but little is known about the role of deubiquitylating (DUB) enzymes in such functions. Budding yeast cells deleted for UBP13 and its close homolog UBP9 displayed a high incidence of petite colonies and slow respiratory growth at 37°C. Both Ubp9 and Ubp13 interacted directly with Duf1 (DUB-associated factor 1), a WD40 motif-containing protein. Duf1 activates the DUB activity of recombinant Ubp9 and Ubp13 i ...[more]