Ontology highlight
ABSTRACT:
SUBMITTER: Abrams MB
PROVIDER: S-EPMC3378614 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Abrams Mathew B MB Nilsson Ingrid I Lewandowski Sebastian A SA Kjell Jacob J Codeluppi Simone S Olson Lars L Eriksson Ulf U
PloS one 20120619 6
We investigated whether imatinib (Gleevec®, Novartis), a tyrosine kinase inhibitor, could improve functional outcome in experimental spinal cord injury. Rats subjected to contusion spinal cord injury were treated orally with imatinib for 5 days beginning 30 minutes after injury. We found that imatinib significantly enhanced blood-spinal cord-barrier integrity, hindlimb locomotor function, sensorimotor integration, and bladder function, as well as attenuated astrogliosis and deposition of chondro ...[more]