Ontology highlight
ABSTRACT:
SUBMITTER: Kraft DJ
PROVIDER: S-EPMC3379025 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Biophysical journal 20120619 12
We put forward a modified Zipper model inspired by the statics and dynamics of the spontaneous reconstitution of rodlike tobacco mosaic virus particles in solutions containing the coat protein and the single-stranded RNA of the virus. An important ingredient of our model is an allosteric switch associated with the binding of the first protein unit to the origin-of-assembly domain of the viral RNA. The subsequent addition and conformational switching of coat proteins to the growing capsid we beli ...[more]