Ontology highlight
ABSTRACT:
SUBMITTER: Wice BM
PROVIDER: S-EPMC3379667 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wice Burton M BM Reeds Dominic N DN Tran Hung D HD Crimmins Dan L DL Patterson Bruce W BW Dunai Judit J Wallendorf Michael J MJ Ladenson Jack H JH Villareal Dennis T DT Polonsky Kenneth S KS
Diabetes 20120420 7
Glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-stimulated insulin secretion (GSIS). This response is blunted in type 2 diabetes (T2DM). Xenin-25 is a 25-amino acid neurotensin-related peptide that amplifies GIP-mediated GSIS in hyperglycemic mice. This study determines if xenin-25 amplifies GIP-mediated GSIS in humans with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or T2DM. Each fasting subject received graded glucose infusions to progressively rais ...[more]