Cholera modeling: challenges to quantitative analysis and predicting the impact of interventions.
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ABSTRACT:
SUBMITTER: Grad YH
PROVIDER: S-EPMC3380087 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Cholera modeling: challenges to quantitative analysis and predicting the impact of interventions.
Grad Yonatan H YH Miller Joel C JC Lipsitch Marc M
Epidemiology (Cambridge, Mass.) 20120701 4
Several mathematical models of epidemic cholera have recently been proposed in response to outbreaks in Zimbabwe and Haiti. These models aim to estimate the dynamics of cholera transmission and the impact of possible interventions, with a goal of providing guidance to policy makers in deciding among alternative courses of action, including vaccination, provision of clean water, and antibiotics. Here, we discuss concerns about model misspecification, parameter uncertainty, and spatial heterogenei ...[more]
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