Ontology highlight
ABSTRACT:
SUBMITTER: Maier CL
PROVIDER: S-EPMC3380367 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Maier Cheryl L CL Pober Jordan S JS
Arteriosclerosis, thrombosis, and vascular biology 20101104 1
<h4>Objective</h4>Cell-mediated immune responses in peripheral tissues begin with T cell infiltration through endothelial cell (EC) microvessels and accumulation in the perivascular space occupied by pericytes (PC). Here, we investigate how human T cells interact with PC.<h4>Methods and results</h4>We compared human placental PC with autologous umbilical vein EC. Cultured PC express lower levels of major histocompatibility complex (MHC) and positive costimulatory molecules but higher levels of n ...[more]