Ontology highlight
ABSTRACT:
SUBMITTER: Bachan S
PROVIDER: S-EPMC3380439 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Bachan Stewart S Fantini Jacques J Joshi Anjali A Garg Himanshu H Mootoo David R DR
Bioorganic & medicinal chemistry 20110701 16
Inspired by the anti-human immunodeficiency virus (HIV) activity of analogues of β-galactosylceramide (GalCer), a set of mono- and di-saccharide fatty acid esters were designed as GalCer mimetics and their binding to the V3 loop peptide of HIV-1 and anti-HIV activity evaluated. 1,1-linked Gal-Man and Glu-Man disaccharides with an ester on the Man subunit bound the V3 loop peptide and inhibited HIV infectivity in single round infection assays with the TZM-bl cell line. IC(50)'s were in the 50 μM ...[more]