Ontology highlight
ABSTRACT:
SUBMITTER: Joensuu H
PROVIDER: S-EPMC3381421 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Joensuu Heikki H DeMatteo Ronald P RP
Annual review of medicine 20111013
Gastrointestinal stromal tumor (GIST) has become a model for targeted therapy in cancer. The vast majority of GISTs contain an activating mutation in either the KIT or platelet-derived growth factor A (PDGFRA) gene. GIST is highly responsive to several selective tyrosine kinase inhibitors. In fact, this cancer has been converted to a chronic disease in some patients. Considerable progress has been made recently in our understanding of the natural history and molecular biology of GIST, risk strat ...[more]