Ontology highlight
ABSTRACT:
SUBMITTER: Teplova M
PROVIDER: S-EPMC3381513 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Teplova Marianna M Song Jikui J Gaw Hai Yan HY Teplov Alexei A Patel Dinshaw J DJ
Structure (London, England : 1993) 20101001 10
CUG-binding protein 1 (CUGBP1) regulates multiple aspects of nuclear and cytoplasmic mRNA processing, with implications for onset of myotonic dystrophy. CUGBP1 harbors three RRM domains and preferentially targets UGU-rich mRNA elements. We describe crystal structures of CUGBP1 RRM1 and tandem RRM1/2 domains bound to RNAs containing tandem UGU(U/G) elements. Both RRM1 in RRM1-RNA and RRM2 in RRM1/2-RNA complexes use similar principles to target UGU(U/G) elements, with recognition mediated by face ...[more]