Ontology highlight
ABSTRACT:
SUBMITTER: Murray PS
PROVIDER: S-EPMC3381843 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Murray Patrick S PS Kirkwood Caitlin M CM Gray Megan C MC Ikonomovic Milos D MD Paljug William R WR Abrahamson Eric E EE Henteleff Ruth A RA Hamilton Ronald L RL Kofler Julia K JK Klunk William E WE Lopez Oscar L OL Penzes Peter P Sweet Robert A RA
Neurobiology of aging 20120317 12
Psychosis in Alzheimer disease differentiates a subgroup with more rapid decline, is heritable, and aggregates within families, suggesting a distinct neurobiology. Evidence indicates that greater impairments of cerebral cortical synapses, particularly in dorsolateral prefrontal cortex, may contribute to the pathogenesis of psychosis in Alzheimer disease (AD) phenotype. Soluble β-amyloid induces loss of dendritic spine synapses through impairment of long-term potentiation. In contrast, the Rho gu ...[more]