Ontology highlight
ABSTRACT:
SUBMITTER: Salegio EA
PROVIDER: S-EPMC3381869 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Gene therapy 20120315 3
We have previously shown that adeno-associated virus type 2 (AAV2) undergoes anterograde axonal transport in rat and non-human primate brain. We screened other AAV serotypes for axonal transport and found that AAV6 is transported almost exclusively in a retrograde direction and, in the same way as AAV2, it is also neuron-specific in rat brain. Our findings show that axonal transport of AAV is serotype dependent and this has implications for gene therapy of neurological diseases such as Huntingto ...[more]