Ontology highlight
ABSTRACT:
SUBMITTER: Witkin KL
PROVIDER: S-EPMC3381997 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Witkin Keren L KL Chong Yolanda Y Shao Sichen S Webster Micah T MT Lahiri Sujoy S Walters Alison D AD Lee Brandon B Koh Judice L Y JL Prinz William A WA Andrews Brenda J BJ Cohen-Fix Orna O
Current biology : CB 20120531 12
The mechanisms that dictate nuclear shape are largely unknown. Here we screened the budding yeast deletion collection for mutants with abnormal nuclear shape. A common phenotype was the appearance of a nuclear extension, particularly in mutants in DNA repair and chromosome segregation genes. Our data suggest that these mutations led to the abnormal nuclear morphology indirectly, by causing a checkpoint-induced cell-cycle delay. Indeed, delaying cells in mitosis by other means also led to the app ...[more]