Ontology highlight
ABSTRACT:
SUBMITTER: Cummins NW
PROVIDER: S-EPMC3382093 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Cummins Nathan W NW Weaver Eric A EA May Shannon M SM Croatt Anthony J AJ Foreman Oded O Kennedy Richard B RB Poland Gregory A GA Barry Michael A MA Nath Karl A KA Badley Andrew D AD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120406 7
Underlying mechanisms of individual variation in severity of influenza infection and response to vaccination are poorly understood. We investigated the effect of reduced heme oxygenase-1 (HO-1) expression on vaccine response and outcome of influenza infection. HO-1-deficient and wild-type (WT) mice (kingdom, Animalia; phylum, Chordata; genus/species, Mus musculus) were infected with influenza virus A/PR/8/34 with or without prior vaccination with an adenoviral-based influenza vaccine. A genome-w ...[more]