Ontology highlight
ABSTRACT:
SUBMITTER: Tchaptchet S
PROVIDER: S-EPMC3382180 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Tchaptchet Sandrine S Gumenscheimer Marina M Kalis Christoph C Freudenberg Nikolaus N Hölscher Christoph C Kirschning Carsten J CJ Lamers Marinus M Galanos Chris C Freudenberg Marina A MA
PloS one 20120622 6
Propionibacterium acnes is usually a relatively harmless commensal. However, under certain, poorly understood conditions it is implicated in the etiology of specific inflammatory diseases. In mice, P. acnes exhibits strong immunomodulatory activity leading to splenomegaly, intrahepatic granuloma formation, hypersensitivity to TLR ligands and endogenous cytokines, and enhanced resistance to infection. All these activities reach a maximum one week after P. acnes priming and require IFN-γ and TLR9. ...[more]