Ontology highlight
ABSTRACT:
SUBMITTER: Rademacher C
PROVIDER: S-EPMC3382346 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Rademacher Christoph C Bru Thierry T McBride Ryan R Robison Elizabeth E Nycholat Corwin M CM Kremer Eric J EJ Paulson James C JC
Glycobiology 20120421 8
Sialic-acid-binding immunoglobulin-like lectins (Siglecs) are a family of transmembrane receptors that are well documented to play roles in regulation of innate and adaptive immune responses. To see whether the features that define the molecular recognition of sialic acid were found in other sialic-acid-binding proteins, we analyzed 127 structures with bound sialic acids found in the Protein Data Bank database. Of these, the canine adenovirus 2-fiber knob protein showed close local structural re ...[more]