Ontology highlight
ABSTRACT:
SUBMITTER: Ouyang L
PROVIDER: S-EPMC3382768 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ouyang Liang L He Gu G Huang Wei W Song Xiangrong X Wu Fengbo F Xiang Mingli M
International journal of molecular sciences 20120502 5
Tryptophan hydroxylase-1 (TPH1) is a key enzyme in the synthesis of serotonin. As a neurotransmitter, serotonin plays important physiological roles both peripherally and centrally. In this study, a combination of ligand-based and structure-based methods is used to clarify the essential quantitative structure-activity relationship (QSAR) of known TPH1 inhibitors. A multicomplex-based pharmacophore (MCBP) guided method has been suggested to generate a comprehensive pharmacophore of TPH1 kinase bas ...[more]