Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.
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ABSTRACT:
SUBMITTER: Dunstone MA
PROVIDER: S-EPMC3383384 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
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Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.
Dunstone Michelle A MA Tweten Rodney K RK
Current opinion in structural biology 20120531 3
The bacterial cholesterol dependent cytolysins (CDCs) and membrane attack complex/perforin-like proteins (MACPF) represent two major branches of a large, exceptionally diverged superfamily. Most characterized CDC/MACPF proteins form large pores that function in immunity, venoms, and pathogenesis. Extensive structural, biochemical and biophysical studies have started to address some of the questions surrounding how the soluble, monomeric form of these remarkable molecules recognize diverse target ...[more]
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