Ontology highlight
ABSTRACT:
SUBMITTER: Demontiero O
PROVIDER: S-EPMC3383520 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Demontiero Oddom O Vidal Christopher C Duque Gustavo G
Therapeutic advances in musculoskeletal disease 20120401 2
It is well known that the underlying mechanisms of osteoporosis in older adults are different than those associated with estrogen deprivation. Age-related bone loss involves a gradual and progressive decline, which is also seen in men. Markedly increased bone resorption leads to the initial fall in bone mineral density. With increasing age, there is also a significant reduction in bone formation. This is mostly due to a shift from osteoblastogenesis to predominant adipogenesis in the bone marrow ...[more]