Phosphatidylserine colocalizes with epichromatin in interphase nuclei and mitotic chromosomes.
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ABSTRACT:
SUBMITTER: Prudovsky I
PROVIDER: S-EPMC3383575 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Phosphatidylserine colocalizes with epichromatin in interphase nuclei and mitotic chromosomes.
Prudovsky Igor I Vary Calvin P H CP Markaki Yolanda Y Olins Ada L AL Olins Donald E DE
Nucleus (Austin, Tex.) 20120301 2
Cycling eukaryotic cells rapidly re-establish the nuclear envelope and internal architecture following mitosis. Studies with a specific anti-nucleosome antibody recently demonstrated that the surface ("epichromatin") of interphase and mitotic chromatin possesses a unique and conserved conformation, suggesting a role in postmitotic nuclear reformation. Here we present evidence showing that the anionic glycerophospholipid phosphatidylserine is specifically located in epichromatin throughout the ce ...[more]
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