Ontology highlight
ABSTRACT:
SUBMITTER: Vaseva AV
PROVIDER: S-EPMC3383624 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Vaseva Angelina V AV Marchenko Natalie D ND Ji Kyungmin K Tsirka Stella E SE Holzmann Sonja S Moll Ute M UM
Cell 20120601 7
Ischemia-associated oxidative damage leading to necrosis is a major cause of catastrophic tissue loss, and elucidating its signaling mechanism is therefore of paramount importance. p53 is a central stress sensor responding to multiple insults, including oxidative stress to orchestrate apoptotic and autophagic cell death. Whether p53 can also activate oxidative stress-induced necrosis is, however, unknown. Here, we uncover a role for p53 in activating necrosis. In response to oxidative stress, p5 ...[more]