Ontology highlight
ABSTRACT:
SUBMITTER: Salazar E
PROVIDER: S-EPMC3383692 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Salazar Eric E Bank Erin M EM Ramsey Nicole N Hess Kenneth C KC Deitsch Kirk W KW Levin Lonny R LR Buck Jochen J
PloS one 20120626 6
The most severe form of human malaria is caused by the parasite Plasmodium falciparum. The second messenger cAMP has been shown to be important for the parasite's ability to infect the host's liver, but its role during parasite growth inside erythrocytes, the stage responsible for symptomatic malaria, is less clear. The P. falciparum genome encodes two adenylyl cyclases, the enzymes that synthesize cAMP, PfACα and PfACβ. We now show that one of these, PfACβ, plays an important role during the er ...[more]