Ontology highlight
ABSTRACT:
SUBMITTER: Kim E
PROVIDER: S-EPMC3383818 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Kim Eunhee E Febbraio Maria M Bao Yi Y Tolhurst Aaron T AT Epstein Jeffrey M JM Cho Sunghee S
Annals of neurology 20120601 6
<h4>Objective</h4>Hyperlipidemia exacerbates ischemic stroke outcome and increases CD36 expression in the postischemic brain as well as in peripheral monocytes/macrophages. By exchanging bone marrow-derived cells between CD36-expressing and CD36-deficient mice, this study investigates the contribution of peripheral CD36 in comparison with that of brain CD36 to stroke pathology in hyperlipidemia.<h4>Methods</h4>Following bone marrow transplantation, mice were fed a high-fat diet for 11 weeks and ...[more]