A gimbal-mounted pressurization chamber for macroscopic and microscopic assessment of ocular tissues.

ABSTRACT: The biomechanical model of glaucoma considers intraocular pressure-related stress and resultant strain on load bearing connective tissues of the optic nerve and surrounding peripapillary sclera as one major causative influence that effects cellular, vascular, and axonal components of the optic nerve. By this reasoning, the quantification of variations in the microstructural architecture and macromechanical response of scleral shells in glaucomatous compared to healthy populations provides an insight into any variations that exist between patient populations. While scleral shells have been tested mechanically in planar and pressure-inflation scenarios the link between the macroscopic biomechanical response and the underlying microstructure has not been determined to date. A potential roadbl

SUBMITTER: Keyes JT 

PROVIDER: S-EPMC3383844 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature