Ontology highlight
ABSTRACT:
SUBMITTER: Veesler D
PROVIDER: S-EPMC3384155 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Veesler David D Spinelli Silvia S Mahony Jennifer J Lichière Julie J Blangy Stéphanie S Bricogne Gérard G Legrand Pierre P Ortiz-Lombardia Miguel M Campanacci Valérie V van Sinderen Douwe D Cambillau Christian C
Proceedings of the National Academy of Sciences of the United States of America 20120518 23
Phages of the Caudovirales order possess a tail that recognizes the host and ensures genome delivery upon infection. The X-ray structure of the approximately 1.8 MDa host adsorption device (baseplate) from the lactococcal phage TP901-1 shows that the receptor-binding proteins are pointing in the direction of the host, suggesting that this organelle is in a conformation ready for host adhesion. This result is in marked contrast with the lactococcal phage p2 situation, whose baseplate is known to ...[more]