Ontology highlight
ABSTRACT:
SUBMITTER: Jin I
PROVIDER: S-EPMC3384209 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Jin Iksung I Puthanveettil Sathya S Udo Hiroshi H Karl Kevin K Kandel Eric R ER Hawkins Robert D RD
Proceedings of the National Academy of Sciences of the United States of America 20120522 23
Long-term plasticity can differ from short-term in recruiting the growth of new synaptic connections, a process that requires the participation of both the presynaptic and postsynaptic components of the synapse. How does information about synaptic plasticity spread from its site of origin to recruit the other component? The answer to this question is not known in most systems. We have investigated the possible role of spontaneous transmitter release as such a transsynaptic signal. Until recently ...[more]