Ontology highlight
ABSTRACT:
SUBMITTER: Ni J
PROVIDER: S-EPMC3384541 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Ni Jing J Liu Qingsong Q Xie Shaozhen S Carlson Coby C Von Thanh T Vogel Kurt K Riddle Steve S Benes Cyril C Eck Michael M Roberts Thomas T Gray Nathanael N Zhao Jean J
Cancer discovery 20120412 5
<h4>Unlabelled</h4>Genetic approaches have shown that the p110β isoform of class Ia phosphatidylinositol-3-kinase (PI3K) is essential for the growth of PTEN-null tumors. Thus, it is desirable to develop p110β-specific inhibitors for cancer therapy. Using a panel of PI3K isoform-specific cellular assays, we screened a collection of compounds possessing activities against kinases in the PI3K superfamily and identified a potent and selective p110β inhibitor: KIN-193. We show that KIN-193 is efficac ...[more]