Ontology highlight
ABSTRACT:
SUBMITTER: Bartlett NW
PROVIDER: S-EPMC3384678 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Bartlett Nathan W NW Walton Ross P RP Edwards Michael R MR Aniscenko Juliya J Caramori Gaetano G Zhu Jie J Glanville Nicholas N Choy Katherine J KJ Jourdan Patrick P Burnet Jerome J Tuthill Tobias J TJ Pedrick Michael S MS Hurle Michael J MJ Plumpton Chris C Sharp Nigel A NA Bussell James N JN Swallow Dallas M DM Schwarze Jurgen J Guy Bruno B Almond Jeffrey W JW Jeffery Peter K PK Lloyd Clare M CM Papi Alberto A Killington Richard A RA Rowlands David J DJ Blair Edward D ED Clarke Neil J NJ Johnston Sebastian L SL
Nature medicine 20080203 2
Rhinoviruses cause serious morbidity and mortality as the major etiological agents of asthma exacerbations and the common cold. A major obstacle to understanding disease pathogenesis and to the development of effective therapies has been the lack of a small-animal model for rhinovirus infection. Of the 100 known rhinovirus serotypes, 90% (the major group) use human intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor and do not bind mouse ICAM-1; the remaining 10% (the minor gro ...[more]