Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice.

ABSTRACT:

Ethnopharmacological relevance

Berberine is an isoquinoline alkaloid isolated from the root and bark of plants such as goldenseal, Berberis, and Chinese goldthread. Berberine-containing crude drugs have been used as an antimicrobial remedy against gastrointestinal infections for thousands of years. It is also widely used in Asian countries for diabetes, hypertension, and hypercholesterolemia therapy.

Aim of the study

Potential drug-drug interactions are of concern because of the wide usage of berberine. A few studies have reported interactions between berberine and cytochromes P450 (CYPs) in vitro, but little is known about whether berberine influences CYPs in vivo, especially after repeated administration. In this study, eight-week-old male C57BL/6 mice were given berberine

SUBMITTER: Guo Y 

PROVIDER: S-EPMC3384737 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature