Dataset Information

Persistent lipophilic environmental chemicals and endometriosis: the ENDO Study.

ABSTRACT:

Background

An equivocal literature exists regarding the relation between persistent organochlorine pollutants (POPs) and endometriosis in women, with differences attributed to methodologies.

Objectives

We assessed the association between POPs and the odds of an endometriosis diagnosis and the consistency of findings by biological medium and study cohort.

Methods

Using a matched cohort design, we assembled an operative cohort of women 18-44 years of age undergoing laparoscopy or laparotomy at 14 participating clinical centers from 2007 to 2009 and a population-based cohort matched on age and residence within a 50-mile catchment area of the clinical centers. Endometriosis was defined as visualized disease in the operative cohort and as diagnosed by magnetic resonance imaging in the population cohort. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for each POP in relation to an endometriosis diagnosis, with separate models run for each medium (omental fat in the operative cohort, serum in both cohorts) and cohort. Adjusted models included age, body mass index, breast-feeding conditional on parity, cotinine, and lipids.

Results

Concentrations were higher in omental fat than in serum for all POPs. In the operative cohort, ?-hexachlorocyclohexane (?-HCH) was the only POP with a significant positive association with endometriosis [per 1-SD increase in log-transformed ?-HCH: adjusted OR (AOR) = 1.27; 95% CI: 1.01, 1.59]; ?-HCH was the only significant predictor in the population cohort (per 1-SD increase in log-transformed ?-HCH: AOR = 1.72; 95% CI: 1.09, 2.72).

Conclusions

Using a matched cohort design, we found that cohort-specific and biological-medium-specific POPs were associated with endometriosis, underscoring the importance of methodological considerations when interpreting findings.

SUBMITTER: Buck Louis GM

PROVIDER: S-EPMC3385438 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Publications

Persistent lipophilic environmental chemicals and endometriosis: the ENDO Study.

Buck Louis Germaine M GM Chen Zhen Z Peterson C Matthew CM Hediger Mary L ML Croughan Mary S MS Sundaram Rajeshwari R Stanford Joseph B JB Varner Michael W MW Fujimoto Victor Y VY Giudice Linda C LC Trumble Ann A Parsons Patrick J PJ Kannan Kurunthachalam K

Environmental health perspectives 20120314 6

<h4>Background</h4>An equivocal literature exists regarding the relation between persistent organochlorine pollutants (POPs) and endometriosis in women, with differences attributed to methodologies.<h4>Objectives</h4>We assessed the association between POPs and the odds of an endometriosis diagnosis and the consistency of findings by biological medium and study cohort.<h4>Methods</h4>Using a matched cohort design, we assembled an operative cohort of women 18-44 years of age undergoing laparoscop ...[more]

PMID: 22417635

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Project description:BackgroundTampons are used by up to 86% of US women and are a rarely considered potential source of pesticide and metal exposure. Tampons may be of particular concern given the likely higher absorption that occurs in the vagina. Our objective was to examine the potential associations between tampon use and metal concentrations, and biomarkers of inflammation and oxidative stress among healthy women.MethodsWe used information from a prospective cohort of 259 regularly menstruating women, aged 18-44, followed for two menstrual cycles. Tampon use was assessed using information provided in participant study diaries. Metal concentrations were measured from a blood sample collected at enrollment. Oxidative stress and inflammation biomarker concentrations were determined from blood samples collected at up to 8 clinic visits for each cycle. Linear regression models were used to estimate associations of tampon use with metal exposure, and linear mixed models to estimate associations of tampon use with inflammation and oxidative stress biomarkers at different times during the menstrual cycle.ResultsWe observed non-significantly higher mean levels of mercury for tampon users compared to non-tampon users (exp(β) = 1.25, 95% CI = 0.93, 1.68). We found no evidence of an association between tampon use and inflammation biomarkers. We observed consistently higher isoprostane levels, an oxidative stress biomarker, among tampon users compared to non-tampon users (e.g. exp.(β) = 1.05, 95%CI = 0.96, 1.16, for the average isoprostane during the menstruating week); however, these results were not statistically significant.ConclusionsWhile our results are not statistically significant, we observed suggestive associations between tampon use and elevated levels of mercury and oxidative stress biomarkers. Although our finding should be interpreted in light of our limitations, they indicate that tampons may be a source of exposure to metals and chemicals that have been largely ignored, and any related health effects are an important public health concern.

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Dataset Information

Persistent lipophilic environmental chemicals and endometriosis: the ENDO Study.

Background

Objectives

Methods

Results

Conclusions

Publications

Persistent lipophilic environmental chemicals and endometriosis: the ENDO Study.

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