Ontology highlight
ABSTRACT:
SUBMITTER: Ahfeldt T
PROVIDER: S-EPMC3385947 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Ahfeldt Tim T Schinzel Robert T RT Lee Youn-Kyoung YK Hendrickson David D Kaplan Adam A Lum David H DH Camahort Raymond R Xia Fang F Shay Jennifer J Rhee Eugene P EP Clish Clary B CB Deo Rahul C RC Shen Tony T Lau Frank H FH Cowley Alicia A Mowrer Greg G Al-Siddiqi Heba H Nahrendorf Matthias M Musunuru Kiran K Gerszten Robert E RE Rinn John L JL Cowan Chad A CA
Nature cell biology 20120115 2
The utility of human pluripotent stem cells is dependent on efficient differentiation protocols that convert these cells into relevant adult cell types. Here we report the robust and efficient differentiation of human pluripotent stem cells into white or brown adipocytes. We found that inducible expression of PPARG2 alone or combined with CEBPB and/or PRDM16 in mesenchymal progenitor cells derived from pluripotent stem cells programmed their development towards a white or brown adipocyte cell fa ...[more]