Templates are available to model nearly all complexes of structurally characterized proteins.

ABSTRACT: Traditional approaches to protein-protein docking sample the binding modes with no regard to similar experimentally determined structures (templates) of protein-protein complexes. Emerging template-based docking approaches utilize such similar complexes to determine the docking predictions. The docking problem assumes the knowledge of the participating proteins' structures. Thus, it provides the possibility of aligning the structures of the proteins and the template complexes. The progress in the development of template-based docking and the vast experience in template-based modeling of individual proteins show that, generally, such approaches are more reliable than the free modeling. The key aspect of this modeling paradigm is the availability of the templates. The current common percepti

SUBMITTER: Kundrotas PJ 

PROVIDER: S-EPMC3386081 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature