In vitro microvessels for the study of angiogenesis and thrombosis.
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ABSTRACT:
SUBMITTER: Zheng Y
PROVIDER: S-EPMC3386137 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
In vitro microvessels for the study of angiogenesis and thrombosis.
Zheng Ying Y Chen Junmei J Craven Michael M Choi Nak Won NW Totorica Samuel S Diaz-Santana Anthony A Kermani Pouneh P Hempstead Barbara B Fischbach-Teschl Claudia C López José A JA Stroock Abraham D AD
Proceedings of the National Academy of Sciences of the United States of America 20120529 24
Microvascular networks support metabolic activity and define microenvironmental conditions within tissues in health and pathology. Recapitulation of functional microvascular structures in vitro could provide a platform for the study of complex vascular phenomena, including angiogenesis and thrombosis. We have engineered living microvascular networks in three-dimensional tissue scaffolds and demonstrated their biofunctionality in vitro. We describe the lithographic technique used to form endothel ...[more]
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