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Health-related quality of life as a predictor of mortality among survivors of AKI.


ABSTRACT: This study examined the relationship between health-related quality of life and subsequent mortality among AKI survivors treated with renal replacement therapy.Multivariable Cox regression models were used to assess the associations between Health Utilities Index Mark 3 (HUI3) and ambulation, emotion, cognition, and pain scores at 60 days and all-cause mortality at 1 year in 60-day AKI survivors (n=439 with evaluable HUI3 assessments) from a randomized multicenter study comparing less- with more-intensive renal replacement therapies.The median 60-day HUI3 index score was 0.32. Patients with evaluable HUI3 data who died between 60 days and 1 year (n=99) were more likely to have lower 60-day median HUI3 scores, higher comorbidity scores, and longer initial hospital stays, and they were more likely to be dialysis-dependent. A 0.1 higher HUI3 index score was associated with a 17% decrease (hazard ratio, 0.83; 95% confidence interval 0.77-0.89) in all-cause mortality after controlling for clinical risk factors. Similar associations were observed for HUI3 ambulation, emotion, cognition, and pain attribute scores.Health-related quality of life measured by HUI3 is an independent predictor of mortality among survivors of AKI after adjusting for clinical risk variables. Poor ambulation and other health-related quality of life attributes are also associated with increased risk of death. Health-related quality of life may provide clinicians with additional information to help identify patients at high risk of mortality after AKI that required renal replacement therapy.

SUBMITTER: Joyce VR 

PROVIDER: S-EPMC3386668 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Health-related quality of life as a predictor of mortality among survivors of AKI.

Joyce Vilija R VR   Smith Mark W MW   Johansen Kirsten L KL   Unruh Mark L ML   Siroka Andrew M AM   O'Connor Theresa Z TZ   Palevsky Paul M PM  

Clinical journal of the American Society of Nephrology : CJASN 20120517 7


<h4>Background and objectives</h4>This study examined the relationship between health-related quality of life and subsequent mortality among AKI survivors treated with renal replacement therapy.<h4>Design, setting, participants, & measurements</h4>Multivariable Cox regression models were used to assess the associations between Health Utilities Index Mark 3 (HUI3) and ambulation, emotion, cognition, and pain scores at 60 days and all-cause mortality at 1 year in 60-day AKI survivors (n=439 with e  ...[more]

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