Ontology highlight
ABSTRACT:
SUBMITTER: Sulkowska JI
PROVIDER: S-EPMC3387036 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Sułkowska Joanna I JI Rawdon Eric J EJ Millett Kenneth C KC Onuchic Jose N JN Stasiak Andrzej A
Proceedings of the National Academy of Sciences of the United States of America 20120608 26
While analyzing all available protein structures for the presence of knots and slipknots, we detected a strict conservation of complex knotting patterns within and between several protein families despite their large sequence divergence. Because protein folding pathways leading to knotted native protein structures are slower and less efficient than those leading to unknotted proteins with similar size and sequence, the strict conservation of the knotting patterns indicates an important physiolog ...[more]