Ontology highlight
ABSTRACT:
SUBMITTER: Bobr A
PROVIDER: S-EPMC3387113 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Bobr Aleh A Igyarto Botond Z BZ Haley Krystal M KM Li Ming O MO Flavell Richard A RA Kaplan Daniel H DH
Proceedings of the National Academy of Sciences of the United States of America 20120611 26
Langerhans cells (LCs) are skin-resident dendritic cells (DC) located in the epidermis that migrate to skin-draining lymph nodes during the steady state and in response to inflammatory stimuli. TGF-β1 is a critical immune regulator that is highly expressed by LCs. The ability to test the functional importance of LC-derived TGF-β1 is complicated by the requirement of TGF-β1 for LC development and by the absence of LCs in mice with an LC-specific ablation of TGF-β1 or its receptor. To overcome the ...[more]