Ontology highlight
ABSTRACT:
SUBMITTER: Hosoi T
PROVIDER: S-EPMC3387139 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Hosoi Toru T Korematsu Kenta K Horie Naohiro N Suezawa Takahiro T Okuma Yasunobu Y Nomura Yasuyuki Y Ozawa Koichiro K
PloS one 20120629 6
Stress signals cause abnormal proteins to accumulate in the endoplasmic reticulum (ER). Such stress is known as ER stress, which has been suggested to be involved in neurodegenerative diseases, diabetes, obesity and cancer. ER stress activates the unfolded protein response (UPR) to reduce levels of abnormal proteins by inducing the production of chaperon proteins such as GRP78, and to attenuate translation through the phosphorylation of eIF2α. However, excessive stress leads to apoptosis by gene ...[more]