Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC3387212 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Zhang Shulin S Wang Yucheng Y Mao Jian-Hua JH Hsieh David D Kim Il-Jin IJ Hu Li-Min LM Xu Zhidong Z Long Hao H Jablons David M DM You Liang L
PloS one 20120629 6
Protein kinase CK2 is frequently elevated in a variety of human cancers. The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance, and its aberrant activation has been indicated in several types of cancer, including lung cancer. In this study, we show that CK2 is positively involved in Hh/Gli signaling in lung cancer cell lines A549 and H1299. First, we found a correlation between CK2α and Gli1 mRNA levels in 100 primary lung cancer tissues. Down-regulation of Gli1 expres ...[more]