Ontology highlight
ABSTRACT:
SUBMITTER: Yilmaz OH
PROVIDER: S-EPMC3387287 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Yilmaz Ömer H ÖH Katajisto Pekka P Lamming Dudley W DW Gültekin Yetis Y Bauer-Rowe Khristian E KE Sengupta Shomit S Birsoy Kivanc K Dursun Abdulmetin A Yilmaz V Onur VO Selig Martin M Nielsen G Petur GP Mino-Kenudson Mari M Zukerberg Lawrence R LR Bhan Atul K AK Deshpande Vikram V Sabatini David M DM
Nature 20120601 7404
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts by reducing mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin. Calorie intake regulates mT ...[more]