Ontology highlight
ABSTRACT:
SUBMITTER: Yilmaz OH
PROVIDER: S-EPMC3387287 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Nature 20120601 7404
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts by reducing mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin. Calorie intake regulates mT ...[more]