Ontology highlight
ABSTRACT:
SUBMITTER: Harris TH
PROVIDER: S-EPMC3387349 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Harris Tajie H TH Banigan Edward J EJ Christian David A DA Konradt Christoph C Tait Wojno Elia D ED Norose Kazumi K Wilson Emma H EH John Beena B Weninger Wolfgang W Luster Andrew D AD Liu Andrea J AJ Hunter Christopher A CA
Nature 20120601 7404
Chemokines have a central role in regulating processes essential to the immune function of T cells, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation. Here we track T cells using multi-photon microscopy to demonstrate that the chemokine CXCL10 enhances the ability of CD8+ T cells to control the pathogen Toxoplasma gondii in the brains of chronically infected mice. This chemokine boosts T-cell function in two different ways: it maintains the effec ...[more]