Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women.

ABSTRACT:

Background

Although smoking has a known association with hot flashes, the factors distinguishing smokers at greatest risk for menopausal symptoms have not been well delineated. Recent evidence supports a relationship between menopausal symptoms and variants in several genes encoding enzymes that metabolize substrates such as sex steriods, xenobiotics, and catechols. It is currently not known whether the impact of smoking on hot flashes is modified by the presence of such variants.

Objective

The objective of the study was to investigate the relationship between smoking and hot flash occurrence as a function of genetic variation in sex steroid-metabolizing enzymes.

Methods

A cross-sectional analysis of data from the Penn Ovarian Aging study, an ongoing population-based

SUBMITTER: Butts SF 

PROVIDER: S-EPMC3387409 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature