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Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections.

ABSTRACT: Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1? levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.

SUBMITTER: Zinkernagel AS

PROVIDER: S-EPMC3388268 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections.

Zinkernagel Annelies S AS Hruz Petr P Uchiyama Satoshi S von Köckritz-Blickwede Maren M Schuepbach Reto A RA Hayashi Tomoko T Carson Dennis A DA Nizet Victor V

Journal of innate immunity 20110819 2

Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models. ...[more]

PMID: 21860217

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