Remotely activated protein-producing nanoparticles.
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ABSTRACT:
SUBMITTER: Schroeder A
PROVIDER: S-EPMC3388722 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Remotely activated protein-producing nanoparticles.
Schroeder Avi A Goldberg Michael S MS Kastrup Christian C Wang Yingxia Y Jiang Shan S Joseph Brian J BJ Levins Christopher G CG Kannan Sneha T ST Langer Robert R Anderson Daniel G DG
Nano letters 20120508 6
The development of responsive nanomaterials, nanoscale systems that actively respond to stimuli, is one general goal of nanotechnology. Here we develop nanoparticles that can be controllably triggered to synthesize proteins. The nanoparticles consist of lipid vesicles filled with the cellular machinery responsible for transcription and translation, including amino acids, ribosomes, and DNA caged with a photolabile protecting group. These particles served as nanofactories capable of producing pro ...[more]
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