Group I and II mammalian PAKs have different modes of activation by Cdc42.
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ABSTRACT:
SUBMITTER: Baskaran Y
PROVIDER: S-EPMC3388789 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
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Group I and II mammalian PAKs have different modes of activation by Cdc42.
Baskaran Yohendran Y Ng Yuen-Wai YW Selamat Widyawilis W Ling Felicia Tay Pei FT Manser Ed E
EMBO reports 20120629 7
p21-activated kinases (PAKs) are Cdc42 effectors found in metazoans, fungi and protozoa. They are subdivided into PAK1-like (group I) or PAK4-like (group II) kinases. Human PAK4 is widely expressed and its regulatory mechanism is unknown. We show that PAK4 is strongly inhibited by a newly identified auto-inhibitory domain (AID) formed by amino acids 20 to 68, which is evolutionarily related to that of other PAKs. In contrast to group I kinases, PAK4 is constitutively phosphorylated on Ser 474 in ...[more]
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