Ontology highlight
ABSTRACT:
SUBMITTER: Zhao F
PROVIDER: S-EPMC3389133 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Zhao Fang F Cannons Jennifer L JL Dutta Mala M Griffiths Gillian M GM Schwartzberg Pamela L PL
Immunity 20120607 6
X-linked lymphoproliferative syndrome, characterized by fatal responses to Epstein-Barr virus infection, is caused by mutations affecting the adaptor SAP, which links SLAM family receptors to downstream signaling. Although cytotoxic defects in SAP-deficient T cells are documented, the mechanism remains unclear. We show that SAP-deficient murine CD8(+) T cells exhibited normal cytotoxicity against fibrosarcoma targets, yet had impaired adhesion to and killing of B cell and low-avidity T cell targ ...[more]