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CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians.

ABSTRACT: The CYP1A1 gene encodes for the enzyme, aryl hydrocarbon hydroxylase, which is involved in the biotransformation of various aromatic tobacco precarcinogens. In the present study, the association between CYP1A1 gene polymorphisms (IVS1-728G > A, Thr461Asn and Ile462Val), and the risk of oral cancer, was examined among 157 patients with oral cancer and 132 age-matched controls, in a south Indian population. The strength of the association between CYP1A1 variants and oral cancer was estimated by logistic regression. It was found that Thr461Asn was not polymorphic. Both IVS1-728G > A and Ile462Val frequencies were consistent with Hardy-Weinberg equilibrium in the control group. There were no significant differences in genotype or haplotype frequencies between controls and cases with oral cancer. Hence, CYP1A1 SNPs can be considered as not being associated with oral cancer at either the genotype or haplotype levels in the population studied.

SUBMITTER: Balaji L

PROVIDER: S-EPMC3389526 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians.

Balaji Lakshmi L Singh Krishna Balaji KB Bhaskar Lakkakula V K S LV

Genetics and molecular biology 20120401 2

The CYP1A1 gene encodes for the enzyme, aryl hydrocarbon hydroxylase, which is involved in the biotransformation of various aromatic tobacco precarcinogens. In the present study, the association between CYP1A1 gene polymorphisms (IVS1-728G > A, Thr461Asn and Ile462Val), and the risk of oral cancer, was examined among 157 patients with oral cancer and 132 age-matched controls, in a south Indian population. The strength of the association between CYP1A1 variants and oral cancer was estimated by lo ...[more]

PMID: 22888287

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