Ontology highlight
ABSTRACT:
SUBMITTER: Raynes Y
PROVIDER: S-EPMC3389705 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Raynes Yevgeniy Y Gazzara Matthew R MR Sniegowski Paul D PD
Evolution; international journal of organic evolution 20120304 7
Mutators have been shown to hitchhike in asexual populations when the anticipated beneficial mutation supply rate of the mutator subpopulation, NU(b) (for subpopulation of size N and beneficial mutation rate U(b)) exceeds that of the wild-type subpopulation. Here, we examine the effect of total population size on mutator dynamics in asexual experimental populations of Saccharomyces cerevisiae. Although mutators quickly hitchhike to fixation in smaller populations, mutator fixation requires more ...[more]